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Manuel, 28, was released by Green Bay Packers.
Wesley, also 28, was cut by New England.
In a flurry of roster moves, the Panthers also claimed three players -- quarterback Matt Moore (Dallas), offensive tackle Frank Omiyale (Atlanta), and tight end Marcus Freeman (Baltimore) -- off waivers. Carolina placed tight end Michael Gaines (shoulder) on injured reserve, officially ending his 2007 season, and waived offensive tackle Rashad Butler and guard Will Montgomery.