Tyrod Taylor, who will start Thursday's preseason game, took nine snaps with the first-team offense and was sacked four times. Three of his other plays were runs, one was a completion to Woods on a short route and another was an attempt to Marquise Goodwin that was broken up by Browns cornerback Tramon Williams.
When Taylor saw three reps with the second team at the end of practice, he underthrew Dezmin Lewis for an incompletion, handed off to Bronson Hill and was sacked again.
Manuel was also sacked once in nine reps with the second-team offense and one-hopped a pass to Lewis at one point.
The problems with the Browns' blitz-heavy scheme extended to Cassel's 11 snaps with the first team. He was sacked three times and had two other passes broken up by Williams.
The Bills also committed three false start penalties and were called for a delay of game.