Manti Te'o, ILB, Notre Dame
The Bills could be in the market for a quarterback depending on how they feel about Ryan Fitzpatrick after this season, but there's no way Barkley has the arm to play in Buffalo in the winter. There is also no wide receiver worth taking this high to fill their need at that position. Te'o would give the team another young defensive leader up the middle with DT Marcell Dareus. He's a three-down linebacker who can handle the point of attack against the run and has shown plenty of ability in underneath coverage.
(Has Geno Smith going 8 to the Cardinals for those who are wondering)